EFFECTS OF VITAMIN B COMPLEX THERAPY ON TEMPORAL VARIATION IN GENTAMICIN NEPHROTOXICITY IN WISTAR RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
The efficacy and toxicity of several drugs is circadian-rhythm dependent, and this can be exploited as a guide to ameliorate such drug toxicity. Gentamicin is an aminoglycoside antibiotic used in treatment of a variety of infections. Its use is however limited by its associated nephrotoxicity. This nephrotoxicity is ameliorated by reduction in dosing frequency to once a day dosing, use of antioxidants and exploration of circadian variation in gentamicin nephrotoxicity. Temporal variation in gentamicin nephrotoxicity and the use of antioxidants at the time of highest nephrotoxicity are alternative ameliorative strategies for this established toxicity. This study compares the effect of concurrent administration of vitamin B complex and gentamicin based on its temporal variation in nephrotoxicity, with alternative approaches of use of a single strategy alone. Young wistar rats of both sexes were used in this study. A nephrotoxic dose of gentamicin was determined from a ten day study with 80, 100 and 120 mg/kg intraperitoneal gentamicin administration using selected biomarkers as indices. Nephrotoxicity was accessed by elevation of serum urea and serum creatinine which are biomarkers of nephrotoxicity and histological changes of the kidney. Administration of 100 mg/kg of gentamicin at 0800, 1200, 2000 and 0000 hours resulted in nephrotoxicity with maximal toxicity observed at 1200 hours where the level of serum urea and creatinine differed significantly (p≤0.05) from the normal saline control and minimal toxicity was seen at the 0000 hour. Histology of the kidneys showed lymphocyte hyperplasia, interstitial haemorrhages, tubular and glomerular necrosis in the 1200 hour group which was observed to be mild in the 0000 hour group. No significant change was seen in the levels of serum electrolytes (Na+ , K+ , Cl+ , Ca2+) and liver function enzymes (ALT, AST and ALP) irrespective of time of treatment. Concurrent administration of vi gentamicin and vitamin B complex at 1200 and 0000 hours resulted in amelioration of gentamicin nephrotoxicity. However, the amelioration produced by the administration of gentamicin alone at the time of minimal toxicity (0000 hour) was greater than that produced by concurrent administration of gentamicin and vitamin B complex at this time point. The administration of gentamicin based on its temporal variation in nephrotoxicity offers better amelioration of nephrotoxicity than concurrent administration of gentamicin at the time of highest toxicity with vitamin B complex in wistar rats.
Related Project Materials
Implementation of a High-Performance Computing System for Large-Scale Genomic Analysis: A Case Study of Federal University, Wukari, Taraba State
Background of the Study :
The advent of next-generation sequencing technologies has led to an exponential increase in genom...
THE EFFECT OF DIGITALIZATION ON FUND ACCOUNTING PROCESSES
Abstract: THE EFFECT OF DIGITALIZATION ON FUND ACCOUNTING PROCESSES
The primary objectives of this study are to: (1) evaluate how digital...
LIQUIDITY MANAGEMENT AND PERFORMANCE OF MANUFACTURING COMPANIES
Abstract
This project focused on liquidity. It manages the performance of a manufacturing company. The aim of this stud...
ASSESSMENT OF YOUTH ORGANIZATION’S PARTICIPATION IN THE PLANNING AND IMPLEMENTATION OF COMMUNITY DEVELOPMENT PROJECTS IN ABIA STATE, NIGERIA
ABSTRACT
The main purpose of this study was to assess youth org...
The Impact of Export Opportunities on Small Business Growth: A Case Study of Katsina State
Background of the Study
Exporting has become an essential growth strategy for small businesses worldwide. It provides acces...
An Investigation of Occupational Hazards Among Road Construction Workers in Kebbi State
Background of the Study
Road construction is one of the most hazardous occupations, exposing workers to a range of occupational risks, in...
A Critical Analysis of Corporate Tax Compliance and Its Effect on Business Performance in Kaduna State
Background of the Study
Corporate tax compliance is a vital aspect of business operations, as it ensures that companies...
The Impact of Natural Resource Endowments on Nigeria’s Regional Economic Disparities
Background of the Study
Natural resource endowments have played a central role in shaping the economic ge...
The Impact of Religious Beliefs on Polio Vaccine Uptake in Kebbi State
Background of the Study
Religious beliefs have a profound influence on health behaviors and decision-making processes. In Kebbi State, wh...
THE ROLE OF THE CHURCH IN ENSURING PEACE AND HARMONY IN THE SOCIETY
ABSTRACT
This study was carried out on examine the role of church in ensuring peace and harmony in the society usi...
